How Long to Lose Weight After Stopping Trazodone

Many people experience weight loss after stopping trazodone, but not all of them lose the same amount of weight. Some people lose a lot of weight quickly, while others experience less of a weight loss. It is important to take trazodone‘s effect on your body into consideration before making significant changes to your diet or exercise regimen. Here is an overview of how long it takes to lose weight after you stop taking trazodone

2 Weeks to Lose Weight

If you experience the most noticeable effects of trazodone‘s weight loss after two weeks of discontinuing the drug, you will likely see some positive results from the drug’s side effects quickly. Studies have shown that trazodone can cause an average weight loss of about 2 weeks, largely due to its effects on the serotonin and norepinephrine transporters. Serotonin and norepinephrine are chemicals that are naturally present in the brain and play a role in mood and energy levels. By inhibiting the reuptake of these chemicals, trazodone allows them to reach their receptors more effectively, ultimately producing a sense of increased happiness and energy. While this may be very appealing to people who experience these effects from the drug, it is also important to remember that trazodone has other side effects that may last longer than its initial weight loss benefits. 

6 Months to A Few Years to Lose Weight

For some people who take trazodone, losing weight quickly is not the main goal, but rather a side effect. Those people may experience a significant and lasting weight loss over the course of several years, typically between 6 months and a few years. This is likely due to trazodone‘s effect on the gonadotropin releasing hormone (GnRH) receptor, specifically its agonistic action at this location. The agonistic action of trazodone at the GnRH receptor inhibits the function of the receptor, preventing the release of gonadotropins, which in turn stops the production of testosterone and delta-4 -androstenedione. While trazodone has significant health benefits, it also has the potential to cause significant health problems over time, so it is important to monitor and discuss any weight loss with your physician. 

Stopping Trazodone Has Different Effects

As mentioned above, some people experience significant weight loss after they stop taking trazodone, while others experience less of a difference. This is largely due to the fact that trazodone interacts with several different receptors in the body, and it is the interaction with the GnRH receptor that causes it to have such a significant effect on weight loss. In one study, individuals who responded to trazodone had an average weight loss of 3 kg (6.6 lbs) in the first month, with benefits continuing for up to a year. In comparison, individuals who did not respond to trazodone had an average weight loss of only 0.6 kg (1.3 lbs) in the first month and remained stable for the entire year. This difference is likely due to the fact that those who responded to trazodone had a significantly higher baseline body mass index (BMI, kg/m2) than those who did not respond to trazodone. The BMI of individuals who respond to trazodone is 28.3 on average, while the BMI of individuals who do not respond is 26.1 on average. Therefore, if you are overweight or obese, you may experience more significant benefits from trazodone than other people, as you are likely to have a higher baseline BMI. It is also important to remember that some people experience benefits from trazodone even if their BMI is in the normal range, so everyone should not assume that they will not lose weight while taking the drug. It is good to see that trazodone has several different positive effects on the body, but it is also important to remember its other side effects. We hope that this article has helped you to understand how long it takes to lose weight after you stop taking trazodone, as well as how much it varies from person to person.